Hello,
Profinet IO data uses Layer 2 for communication, thus it will not work over a VPN like Wireguard, which operates on Layer 3. Profinet will be implemented into our upcoming switch, however, at the moment it is not supported.
EDIT: If Profinet TCP/IP is used, then it should be routable, but at the control level, usually L2 Profinet is used.
Best regards,
DaumantasG